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Charles River Laboratories Embryology Technologist / Microinjectionist in Wilmington, Massachusetts

Embryology Technologist / Microinjectionist

Req ID #: 109972

Location:

Wilmington, MA, US, 01887

For 70 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform. In return, we’ll help you build a career that you can feel passionate about.

Job Summary

The GEMS Embryology department is looking for an Embryology Technologist / Microinjectionist. The Technologist, under general supervision, will perform all aspects of model creation of rodents using a variety of methods including pronuclear, CRISPR, 8 cell and blastocyst microinjections and or/electroporation. The individual will need to inject embryos and conduct surgical embryo transfer of injected embryos into recipient mice and rats. Duties would include preparation microinjection needles, cell culture, schedule of microinjections, assist with collection of embryos, and ordering of supplies. Other responsibilities may sometimes include the ability to maintain and monitor the production of embryos via in vitro.

ESSENTIAL DUTIES AND RESPONSIBILITIES:

  • Experience in performing microinjection procedures for both embryonic stem (ES) cells both at the 8 cell and blastocyst stage.

  • Experience in CRISPR microinjection.

  • Electroporation of embryos is desired.

  • Conduct embryo transfer (oviductal/uterine) using aspect surgical techniques.

  • Collection of embryos from oviduct and uterine tissue from naturally mated rodents.

  • Generate rodent embryos using IVF technology.

  • Collection of spermatozoa from rodents for routine sperm cryopreservation.

  • Collection of embryos from IVF and natural mating for routine embryo cryopreservation.

  • Conduct QC procedure for cryopreserved material.

  • Maintain cryo-inventory and ensure maintenance of cryo storage units.

  • Experience performing animal husbandry using gnotobiotic isolators, including monitoring animal’s food, water and bedding conditions.

  • Introduction into gnotobiotic isolators basic husbandry supplies including food, cages, bedding, water and environmental enrichment.

  • Comfortable handling rodents (mice and rats), including restraining of animals for collection of fecal pellets, ear/tail sampling as well as tagging animals for identification.

  • Must be comfortable performing mouse/rat health checks and interacting with veterinary staff as necessary.

  • Assist supervisors with mentoring and training of new personnel.

  • May act as team leader in specific departmental projects.

  • Understand and comply with all Standard Operating Procedures (SOPs).

  • Strictly follow all biosecurity procedures necessary to maintain isolator integrity and animal health status, including the proper sterilization and entry of supplies/animals into gnotobiotic isolators.

  • Ensure proper record-keeping and report preparation; ensure data entry into Internet Colony Management (ICM).

  • Ensure compliance with all local, state and federal laws governing the use of research animals.

  • Demonstrated performance to use knowledge and skills when needed.

  • Ability to maintain detailed records and observations.

  • Ability to work under deadlines with general guidance.

  • Excellent organization skill and demonstrated ability to accurately complete detailed work.

  • Weekends and holidays may be required.

  • Perform general housekeeping and adhere to safety procedures.

  • General computer skills and ability to quickly learn and master computer programs, databases and other applications.

  • Perform all other related duties as assigned.

MINIMUM QUALIFICATIONS:

  • Associate degree (A.A. /A.S.) or higher degree equivalent in Biological Science, Lab Animal Science or related discipline.

  • 2 years related experience and/or training.

  • An equivalent combination of education and experience may be accepted as a satisfactory substitute for the specific education and experience listed above.

  • Proficient in computers (ie: MS Office Suite and knowledge of databases).

  • Must possess a high level of initiative and ability to work with little supervision.

  • Broad knowledge of biology laboratory practices.

  • Knowledge and experience in rodent disease models.

PREFERRED QUALIFICATIONS:

  • Master's degree.

  • AALAS certification at the ALATG or above.

About Research Models & Services

Fundamental to basic research and discovery is the use of in vivo models to help identify disease targets and determine potential biological pathways that regulate the condition. As the world’s leader in the production and distribution of the highest quality research animal, with 1 out of 2 animal models produced for preclinical research globally, we understand the importance of this step. With seven decades of experience, our expertise is unmatched, allowing us to provide you with the perfect model, including disease-specific and preconditioned options, for basic research and beyond.

About Charles River

Charles River is an early-stage contract research organization (CRO). We have built upon our foundation of laboratory animal medicine and science to develop a diverse portfolio of discovery and safety assessment services, both Good Laboratory Practice (GLP) and non-GLP, to support clients from target identification through preclinical development. Charles River also provides a suite of products and services to support our clients’ clinical laboratory testing needs and manufacturing activities. Utilizing this broad portfolio of products and services enables our clients to create a more flexible drug development model, which reduces their costs, enhances their productivity and effectiveness to increase speed to market.

With over 17,000 employees within 90 facilities in 20 countries around the globe, we are strategically positioned to coordinate worldwide resources and apply multidisciplinary perspectives in resolving our client’s unique challenges. Our client base includes global pharmaceutical companies, biotechnology companies, government agencies and hospitals and academic institutions around the world. And in 2019, revenue increased to $2.62 billion.

At Charles River, we are passionate about our role in improving the quality of people’s lives. Our mission, our excellent science and our strong sense of purpose guide us in all that we do, and we approach each day with the knowledge that our work helps to improve the health and well-being of many across the globe. We have proudly supported the development of 85% of the drugs approved by the FDA in 2019.

Equal Employment Opportunity

Charles River Laboratories is an Equal Opportunity Employer - M/F/Disabled/Vet.

If you are interested in applying to Charles River Laboratories and need special assistance or an accommodation due to a disability to complete any forms or to otherwise participate in the resume submission process, please contact a member of our Human Resources team by sending an e-mail message to crrecruitment_US@crl.com. This contact is for accommodation requests for individuals with disabilities only and cannot be used to inquire about the status of applications.

For more information, please visit www.criver.com.

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